Oxalyl Chloride – High-Purity Reagent for Chemical Synthesis

Description

Oxalyl Chloride is a versatile, high-purity reagent commonly used in organic synthesis, particularly for converting carboxylic acids to acid chlorides and esters. With its reactive properties, it serves as a crucial component in the pharmaceutical, agrochemical, and specialty chemical industries.

Applications for Oxalyl Chloride:

• Organic Synthesis:
  • Acid Chloride Preparation: Converts carboxylic acids to acid chlorides, which are precursors for esters, amides, and other derivatives.
  • Esterification and Amidation Reactions: Facilitates the synthesis of esters and amides used in pharmaceuticals and fine chemicals.
  • Vilsmeier-Haack Reaction: Key reagent for converting aromatic compounds into aldehydes.
• Pharmaceutical Industry:
  • Used in the synthesis of active pharmaceutical ingredients (APIs).
  • Essential for creating intermediates in drug production.
  • Facilitates the development of specialty compounds for research and therapeutic use.
• Agrochemical Industry:
  • Plays a role in the synthesis of pesticides, herbicides, and insecticides.
  • Used to create key intermediates for crop protection chemicals.
• Polymer and Material Science:
  • Employed in the modification of polymers and resins to enhance performance and durability.
  • Useful in producing specialty coatings and adhesives.
• Specialty Chemicals:
  • Utilized in the production of dyes, fragrances, and flavor compounds.
  • Enables the creation of custom fine chemicals for niche applications.
• Textile Industry:
  • Used to produce intermediates for fabric treatments and finishes.
• Research and Development:
  • A critical reagent for laboratory-scale synthesis and exploratory research in organic chemistry.
  • Used in academic and industrial research for developing new chemical methodologies.
• Industrial Applications:
  • Employed in the production of advanced materials, including high-performance composites and coatings.
  • Integral to manufacturing processes that require reactive intermediates.

Storage:

• Temperature: Store in a cool, dry, and well-ventilated area. Ideal storage temperature is 2–8°C (35–46°F) to prevent decomposition.
• Containers:
  • Use tightly sealed containers made of compatible materials such as glass or Teflon-lined containers.
  • Avoid metal containers, as Oxalyl Chloride is corrosive to most metals.
• Location:
  • Keep away from moisture, direct sunlight, and heat sources.
  • Store separately from water, alcohols, amines, and other incompatible substances to prevent hazardous reactions.
• Labeling: Clearly label containers with hazard warnings and proper storage instructions.

Handling:

• Personal Protective Equipment (PPE):
  • Eye Protection: Chemical splash goggles or a full-face shield.
  • Skin Protection: Chemical-resistant gloves (e.g., nitrile or butyl rubber) and protective clothing.
  • Respiratory Protection: Use a respirator approved for acid gases when working in areas with poor ventilation or potential vapor exposure.
• Ventilation: Always handle Oxalyl Chloride in a fume hood or a well-ventilated area to minimize exposure to vapors.
• Safe Practices:
  • Avoid inhalation, ingestion, and contact with skin or eyes.
  • Handle carefully to prevent spills or leaks, as Oxalyl Chloride reacts violently with water, releasing toxic gases (e.g., hydrogen chloride and carbon monoxide).
  • Do not open containers in humid conditions to avoid moisture-induced reactions.

Spill and Leak Management:

• Small Spills:
  • Absorb using an inert material such as dry sand or vermiculite.
  • Neutralize residues with a suitable agent (e.g., soda ash or lime).
  • Dispose of waste according to local regulations.
• Large Spills:
  • Evacuate the area and restrict access.
  • Ensure proper ventilation and wear full protective gear, including a respirator.
  • Contain and neutralize the spill before cleanup.

Disposal:

Dispose of Oxalyl Chloride and its residues in compliance with local, state, and federal regulations. Ensure disposal by a licensed hazardous waste disposal service.