Polysorbate 80 (USP/NF) – Pharmaceautical Grade
$24.99 – $45.00
Technical Specifications
- Chemical Name: Polysorbate 80 (Polyoxyethylene (20) sorbitan monooleate)
- CAS Number: 9005-65-6
- Molecular Formula: C64H124O26
- Molecular Weight: ~1310 g/mol
- Appearance: Amber to yellow viscous liquid
- Grade: Pharmaceutical Grade (USP/NF compliant)
- Solubility: Soluble in water, ethanol, methanol, and ethyl acetate; insoluble in mineral oil and vegetable oils.
- Density: ~1.06 g/cm³ at 25°C
- Viscosity: 300-500 cP at 25°C
- Hydrophilic-Lipophilic Balance (HLB): ~15
- pH: 5.0-7.0 (10% aqueous solution at 25°C)
- Peroxide Value: ≤10.0 meq/kg
- Saponification Value: 45-55 mg KOH/g
- Acid Value: ≤2.0 mg KOH/g
- Hydroxyl Value: 65-80 mg KOH/g
- Residue on Ignition: ≤0.25%
- Storage Conditions: Store in a tightly sealed container, protected from light, at a temperature of 15-30°C.
- Shelf Life: Typically 24 months when stored properly.
- Applications:
- Emulsifying agent for pharmaceuticals, cosmetics, and food products.
- Stabilizer in drug formulations and injectable solutions.
- Solubilizer for vitamins and essential oils.
- Surfactant for cream and lotion formulations.
- Excipient in vaccine production.
- Regulatory Compliance:
- Conforms to USP/NF standards.
- Approved for use in pharmaceuticals and food by major regulatory agencies (FDA, EMA).
- GHS Hazard Classification:
- Hazard Statements: Generally recognized as safe; not classified as hazardous under GHS.
- Precautionary Statements: Avoid prolonged contact with skin and eyes; use in well-ventilated areas.
Documents:
Description
Polysorbate 80 is a nonionic surfactant and emulsifier commonly used in medications, foods, and cosmetics. This synthetic chemical produces a thick, water-soluble yellow liquid.
Polysorbate 80 is used as a food emulsifier, but research suggests it may “profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states. It can also be used as a surfactant in soaps and cosmetics (including eyedrops) or as a solubilizer in mouthwash. The cosmetic grade of polysorbate 80 may have more contaminants than the food grade. It is also used as a surfactant and solubilizer in a wide range of oral and topical medicinal preparations.
Applications for Polysorbate 80 (USP/NF):
Pharmaceutical Applications:
- Injectable Solutions:
- Used as a solubilizer and stabilizer in drug formulations.
- Enhances the delivery of hydrophobic active ingredients.
- Commonly found in vaccines and biologics.
- Topical Formulations:
- Emulsifies and stabilizes creams, ointments, and gels.
- Improves the consistency and spreadability of topical medications.
- Oral Solutions & Suspensions:
- Acts as an emulsifying agent in syrups and elixirs.
- Ensures uniform distribution of active ingredients.
- Tablets & Capsules:
- Aids in the solubilization of poorly water-soluble drugs.
Cosmetic Applications:
- Lotions and Creams:
- Provides smooth, stable emulsions for moisturizers and anti-aging products.
- Ensures consistency in oil-and-water-based formulations.
- Hair Care Products:
- Used in shampoos, conditioners, and styling products to mix water and oil phases.
- Serums & Facial Sprays:
- Enhances solubility and stability of active ingredients in lightweight products.
- Bath Products:
- Stabilizes and emulsifies bath oils and bubble baths.
Food Industry Applications:
- Baked Goods:
- Acts as a dough conditioner to improve texture and elasticity.
- Ice Cream and Desserts:
- Ensures smoothness and prevents the separation of fats and water.
- Sauces and Dressings:
- Stabilizes emulsions in salad dressings, mayonnaise, and gravies.
- Beverages:
- Keeps flavors and colors evenly dispersed in drinks.
Industrial Applications:
- Paints and Coatings:
- Ensures smooth dispersion of pigments and reduces surface tension.
- Textile and Leather Processing:
- Acts as a wetting and dispersing agent.
- Cleaning Products:
- Helps stabilize formulations in detergents and household cleaners.
Additional information
Size | 500mL (16 Fl Oz), 1000ml (32 Fl Oz) |
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